Billard, T.

Chauveau, F.

Lancelot, S.

Levigoureux, E.

Mendjel, M.

Verdurand, M.

Zimmer, L.

HAL Descartes

A screening assay in the search of an alpha-synuclein PET radioligand

Verdurand, Mathieu

Mendjel-Herda, Meriem

Levigoureux, Elise

Lancelot, Sophie

Zeinyeh, Waël

Alazet, Sébastien

Billard, Thierry

Zimmer, Luc

Chauveau, Fabien

HAL-UJM

Hal-Diderot

International audienceThe accumulation of aggregated α-synuclein (α-Syn) in multiple brain regions is a neuropathological hallmark of synucleinopathies like Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. A pre-mortem diagnosis tool would improve early diagnosis, monitor disease progression and therapeutic efficacy. While suitable amyloid-β (Aβ) PET radiotracers have been developed, no selective α-Syn PET ligand has been identified to date. One PET tracer, BF227, labelled with carbon-11 or fluor-18, has demonstrated interesting binding properties towards α-Syn fibrils in vitro (1) and α-Syn glial inclusions in MSA patients (2)

https://hal.archives-ouvertes.fr/hal-01207698

A screening assay in the search of an alpha-synuclein PET radioligand

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HAL Descartes

HAL-UJM

Hal-Diderot

Hal-Diderot

HAL Descartes

HAL-UJM