摘要 目的：金黄色葡萄球菌(Staphylococcusaureus)分泌的毒性休克综合征毒素-1(ToxicShockSyndromeToxin-1，TSST-1)引发中毒性休克综合征(ToxicShockSyndrome，TSS)，通过激活T淋巴细胞使其活化、增殖，引起强烈的免疫应答。目前针对TSST-1本身的治疗手段不多，合成寡核苷酸文库和亲和力筛选作为获得高亲和力、高特异性适配体(Aptamer)的一种方便、快捷、有效的方法。本研究利用指数富集的配体系统进化技术(SystematicEvolutionofLigandsbyExponentialEnrichment，SELEX)筛选具...Abstract Objective: Toxic Shock Syndrome Toxin-1(TSST-1) that can lead to toxic shock syndrome(TSS) is a toxin secreted by Staphylococcus aureus(S.aureus).TSST-1 is a superantigen for T-lymphocytes and activates production of immune signaling molecules. Explorations for new drugs, methods and regimens against TSST-1 have not stop yet and will continue. The synthesis of oligonucleotide library...学位：医学硕士院系专业：医学院_临床检验诊断学学号：2452013115349
