树突状细胞(Dendriticcells，DCs)是机体最为重要的抗原提呈细胞(Antigenpresentingcell，APC)。DCs对抗原的交叉提呈是指外源性抗原被DCs摄取和加工后，与MHCI类分子结合形成CD8+特异性抗原肽-MHCI类分子复合物的过程，可使T细胞分化为CD8+特异性细胞毒T细胞(CytotoxicTlymphocyte，CTL)。甘露糖受体(Mannosereceptor，MR)是DCs表面重要的的模式识别受体(Patternrecognitionreceptor，PRR)，DCs对可溶性抗原的交叉提呈依赖于MR介导的抗原内吞及MR的泛素化修饰。但迄今为止，泛素化...Dendritic cells (DCs) are the most important antigen presenting cells (APCs) in adaptive immune response. Cross-presentation refers to the process that internalized exogenous antigens was processed and combined with MHC class I to form the peptide-MHC class I complex, which contribute to T cell activation and CTL differention. Mannose receptor (MR) is a critical pathogen recognition receptor in DC...学位：理学硕士院系专业：医学院_微生物学学号：2452013115345
