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The role of TNFAIP8 family in gastric cancer and heart transplantation

Abstract

摘要 目的:TIPE及TIPE2是TNFAIP8(Tumornecrosisfactor-αinducedprotein-8,TIPE,TNFAIP8)家族的重要成员,TIPE是调控凋亡进程的重要分子,本研究之一是应用TIPE不同表达的BGC823细胞株建立胃癌裸鼠移植瘤模型,观察TIPE对移植瘤生长的影响;同时收集并检测胃癌临床标本TIPE的表达特点,分析TIPE与胃癌临床病理特征的关系,明确TIPE与胃癌生物学行为的关系及对胃癌生长的影响。 TIPE2为免疫负性调控因子,对免疫稳态的维持起重要作用。本研究之二为构建异种心脏移植模型,在移植后的不同时间点收集移植物和脾脏组织,检测TIPE...ABSTRACT Objective: As is known, TIPE and TIPE2 are important members of TNFAIP8(Tumor necrosis factor-α induced protein-8,TIPE,TNFAIP8) family. Since TIPE is a recently discovered antiapoptotic molecule, part of this study focuses on constructing a nude-mouse transplanted tumor model with the BGC823 cell strain--different expression of TIPE, and observing the influences TIPE has on the growth of...学位:医学硕士院系专业:医学院_外科学学号:2452013115349

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