炎症性肠病（IBD）的发生，被认为是遗传、环境和黏膜免疫三方面因素共同作用的结果,而肠黏膜异常的免疫应答又是发病的关键因素之一。在炎症局部，炎性细胞的招募和激活依赖各种细胞膜受体及整合素与细胞基质（ECM）间的相互作用。细胞外基质蛋白Mindin是Mindin/F-spondin家族成员，在小鼠炎症模型中，有多项研究表明Mindin在免疫应答过程中扮演重要角色，但对于其在炎症中的功能和调控机制研究较少。故本课题拟探索肠炎中Mindin的表达水平及其在炎症中的信号调控机制。 本课题研究中，我们给予C57BL/6小鼠3%的DSS溶液构建急性肠炎模型，提取模型小鼠肠道组织mRNA，通过实时定量PC...Inflammatory bowel disease (IBD) is a group of chronic inflammatory gastrointestinal diseases with complicated etiology and pathogenesis, which is believed to be related to many factors such as intestinal environment , heredity and immunity. Dysfunctions of the immune system has been seen as an important one among the factors. The leukocyte recruitment to inflammatory area and its activation dep...学位：医学硕士院系专业：医学院_内科学学号：2452012115313
