第一部分Pygopus-2在HCC中高表达与病人恶性预后密切相关 Pygopus-2是经典Wnt/β-Catenin信号通路转录复合体的重要成分。本研究目的是观察在原发性肝癌中Pygopus-2的表达情况及相关的临床病理意义。RT-PCR的方法检测50对肝癌病人组织标本中癌组织与癌旁组织中Pygopus-2的mRNA表达情况，结果发现癌组织中Pygopus-2的mRNA水平明显高于癌旁组织(P=0.009)。免疫组化分析显示异常表达的Pygopus-2蛋白与肝癌病人的年龄(P=0.025)、肿瘤大小(P=0.005)、肝内外转移(P=0.029)、组织分化(P=0.004)以及脉管癌栓侵犯(...Part 1 Abnormal nuclear expression of Pygopus-2 in human primary hepatocellular carcinoma correlates with a poor prognosis Pygopus-2 (Pygo2) is a critical element of thecanonical Wnt/β-Catenin transcriptional complex. The aim of the present study was to investigate theexpression patterns and clinic pathological significance of Pygo2 in human primary hepatocellular carcinoma (HCC). Real-time poly...学位：医学硕士院系专业：医学院_外科学学号：2452013115350
