Endoplasmic Reticulum Stress in RGC lesions in DR: Protective Role of an aqueous extract of Radix Astragali， Radix Angelica Sinensis and Panax Notoginseng
目的：早期糖尿病视网膜病变包括神经病变与血管病变，且神经病变可能早于并加剧血管病变的发生，然而现有的治疗方式大多靶向血管病变且疗效有限。我们既往研究表明当归补血汤加味方(RRP)可有效缓解早期糖尿病视网膜的血管病变，也能减少视网膜内神经节细胞的凋亡。已知ERstress广泛存在于应激的真核细胞内，并在糖尿病视网膜病变所致炎症和细胞凋亡中发挥重要作用。本研究拟探索当归补血汤加味方(RRP)对糖尿病视网膜神经节细胞(RGC)内质网应激的作用及其与神经节损伤的关系及其调控机制。 材料与方法：本课题结合STZ诱导1型糖尿病SD大鼠模型和RGC-5细胞缺氧诱导模型，采用HE染色检测并计算眼球切片视网膜...OBJECTIVE— Microvascular and neural dysfunction are hallmarks of Diabetic retinopathy (DR),in which neural dysfunction may occur earlier and exacerbate microvascular dysfunction. So far, most treatments for DR are targeting microvascular dysfunction, however, with limited effects indicating that more attention for neural dysfunction are required. we proposed and proved that an aqueous extract of R...学位：医学硕士院系专业：医学院_内科学学号：2452013115346
