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Mechanistically Investigation for The Significance of Secreted Proteins in Diagnosis of Breast Cancer

Abstract

分泌蛋白对于乳腺癌的发生、发展起着至关重要的作用。有研究表明,分泌蛋白协同作用可促进正常乳腺细胞在软琼脂上的生长,结果提示多个分泌蛋白水平的变化可能是乳腺癌发生、恶化的标志。本研究拟利用乳腺癌临床血液样本,分析血清中几种分泌蛋白的含量,探讨几种分泌蛋白联用在乳腺癌诊断中的意义,并进一步研究这些分泌蛋白在促进乳腺癌细胞迁移、侵袭过程中的作用。 本文首先用ELISA双抗体夹心方法检测临床血清样本中IL6、IL9、IL21、FGF1、FGF10、FGF14的含量,结果表明IL6,FGF1,FGF10三种蛋白在恶性的乳腺癌病人血清中的含量高于对照组的:其中IL6在大多数恶性病人血清中的含量更是超过了...Secreted proteins plays a vital role in breast cancer occurrence and development . The previous investigation demonstrated that Secreted proteins synergistically promote the growth of normal breast cells in soft agar, suggesting that the marked change in multiple secreted proteins may be related to breast cancer. In this study ,we analyzed the content of several secreted proteins in the clinical s...学位:理学硕士院系专业:药学院_化学生物学学号:3232013115337

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