结直肠癌（CRC）新发病率及死亡率在男性女性中均位于第三位，近几年发病率及死亡率呈上升趋势，远处转移尤其肝脏转移为主要死亡原因。研究证实，转化生长因子β1（TGF-β1）在不同的结直肠癌细胞中可以诱导上皮间质化（EMT），上皮间质化（EMT）是肿瘤细胞转移过程中普遍发生的现象；Smad4是TGF-β1作用中的调节枢纽：当Smad4表达时，TGF-β1/Smad4起到抑制转移作用，当Smad4表达缺失时，Smad4非依赖通路活性增强并促进癌细胞转移。据文献报道，EPHA2在多种肿瘤中高表达，促进癌细胞转移及耐化疗药物，是一种促癌基因，近几年成为研究热点之一，作用机制受PI3K/AKT通路调节，而...The mortality and incidence of colorectal cancer (CRC) is in the third, which is gradually rising. Distant metastases is the most important cause of death. Study confirmed that transforming growth factor (TGF-β1) is important inducing cytokines of epithelial-mesenchymal technology (EMT) in different colorectal cancer and EMT is an inevitable phenomenon of tumor metastasis; Smad4 is a key point ...学位：医学硕士院系专业：医学院_外科学学号：2452013115350
