甲亢性心脏病(HyperthyroidHeartDisease,HHD)是甲状腺功能亢进(Hyperthyrodism)的严重并发症,严重危害患者的生命健康,但其机制尚未完全阐明。心磷脂(Cardiolipin,CL)是主要位于线粒体内膜的特殊磷脂,在维持正常的线粒体功能中具有至关重要的作用。本课题组前期研究表明甲亢小鼠心脏中心磷脂含量升高,并且心磷脂参与甲亢性心脏病的病理过程。此外,文献资料显示甲亢会引起心磷脂侧链的C18:2的丢失,同时引起侧链中多不饱和脂肪酸含量的增多,心磷脂侧链结构的变化增加了其侧链的不饱和度以及过氧化度指数,从而可能会增加氧自由基的生成。至于甲亢中心磷脂侧链不饱和度的...Despite hyperthyroid heart disease (HHD) is a serious complication of hyperthyrodism damaging organism’s health, its mechanism remains unclear. Cardiolipin is a unique phospholipid present predominantly in mitochondrial inner membrane. It plays a vital role in the regulation of apoptotic cell death as well as in several cellular metabolic processes, including energy supply. Recent evidence indicat...学位:理学硕士院系专业:医学院_生理学学号:2452012115314