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Bio-guide Screening of Latent HIV Activators from Secondary Metabolites in Anoectochilus Roxburghii Symbiotic Fungis and Exploration of The Mechanisms

Abstract

现行的艾滋病主要治疗手段是高效抗逆转录酶疗法,即俗称的鸡尾酒疗法,该疗法可以有效地抑制HIV病毒的复制,降低病人体内病毒颗粒的数量,有效延长病人生存期。但是鸡尾酒疗法并不能彻底清除病人体内的HIV-1病毒,同时还会产生耐药性,并伴随着较强的毒副作用,因此需要寻找新的治疗手段,彻底治愈艾滋病。“Shockandkill”疗法通过清除HIV病毒潜伏库的方式彻底治愈艾滋病,一经提出便受到国际间的广泛关注。 天然产物具有结构独特、生物活性广泛和不易耐药等特点,逐渐成为新药研发的热点。本实验室与厦门大学药学院天然产物中心合作,希望能够在植物共生真菌的次生代谢产物中筛选到低毒、有效的潜伏期HIV病毒激活...The current therapy of AIDS is HARRT(highly active antiretroviral treatment, HAART), which is also called cocktail therapy. It can effectively inhibit the replication of HIV virus, reduce the number of virus particles and prolong the survival time of patients. But the HARRT therapy cannot completely remove HIV-1 virus, leading to drug resistance and producing strong toxic side effects. It is neces...学位:理学硕士院系专业:药学院_化学生物学学号:3232013115339

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