磷酸化是一种重要的蛋白质翻译后修饰类型。磷酸化和去磷酸化这一可逆过程受蛋白激酶和磷酸酶协同作用控制。作为一种分子开关，蛋白质的磷酸化修饰在包括新陈代谢、转录、细胞周期、细胞分化、细胞骨架的形成、细胞凋亡、细胞通讯和免疫功能在内的整个信号通路与细胞的生命进程中起了至关重要的作用。同源异型蛋白是一类含有同源异型结构域的转录因子，控制着增殖、分化、凋亡等许多细胞进程。Arx(Aristaless-relatedhomeoboxprotein)蛋白作为paired-like型同源异型转录因子，主要在前脑、胰腺、睾丸和肌肉的发育中发挥重要作用。ARX基因的突变与X染色体连锁的智力障碍、无脑回畸形以及小鼠...Phosphorylation is an important post-translational modification of proteins, which is a reversible process that is mediated by kinases and phosphatases. As a molecular switch, phosphorylation plays essential roles in nearly every aspect of cell life including signalling pathways and cellular processes that mediate metabolism, transcription, cell-cycle progression, differentiation, cytoskeleton arr...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2162012115243
