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Actinobacterial Diversity in Depositional Environment of the Southwest India Ocean Ridge and Polyphasic Taxonomy of Five Marine Actinobacteria

Abstract

随着各类拮抗病原菌和顽固性病原菌的出现,以及人们对抗病毒、抗肿瘤等低毒性药物需求的增加,海洋微生物活性次生代谢产物已经成为全球创新药物新的增长点。放线菌是一类重要的药用微生物资源,一百多年来,陆生放线菌资源的研究和开发利用取得了极其辉煌的成就;但受资源获取的限制,目前人们对海洋放线菌的研究还未完全展开。本论文以西南印度洋中脊沉积环境采集的海洋生物样品为基础,对其中的放线菌进行分离方法、生物学特性和系统分类学研究,并结合克隆文库方法对其中放线菌的多样性进行研究;对于发现的新分类单元菌株,进行系统多相分类鉴定,确定其系统发育地位;通过抑菌活性筛选及其功能基因的扩增,对分离菌株次级代谢产物的产生能力...With the emergence of various types of antagonist resistant pathogenic bacteria, and the increase of demand for drugs against the virus and tumor with low toxicity, secondary metabolites with good activity of marine microorganisms has become a new growth point of the global drug innovation. Actinobacteria is a kind of important resources of medicinal microorganisms. Over the past 100 years, resear...学位:理学硕士院系专业:生命科学学院_微生物学学号:2162012115238

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