TRAF6蛋白在LPS/TLR4介导的MyD88依赖型的信号通路中起核心的作用，目前已有报道TAK1作为TRAF6的下游底物，与TAB1/TAB2/TAB3形成复合物，进而激活NF-kB、MAPK信号通路，促进细胞炎症因子的释放。但是，随后有实验室利用最新基因敲除技术在小鼠或细胞水平敲掉TAK1、TAB1、TAB2，MEKK3等基因后，用LPS刺激诱导MyD88依赖型信号通路，发现对NF-kB和MAPK信号通路均没有影响。因此，在LPS诱导的LPS/TLR4/MyD88信号通路中，目前对TRAF6下游蛋白及连接NF-kB、MAPK信号通路的上游这一中间区域还有待挖掘并找到新型的介导分子。 我...TRAF6 plays a crucial role in LPS/TLR4 mediated signaling pathway.However,the downstream substrates of TRAF6 are controversial.So far, it has been reported that TAK1 is the downstream substrate of LPS/TLR4/TRAF6 signaling pathway,TAK1 forms complex with TAB1/TAB2/TAB3 and subsequently activates NF-kB and MAPK signaling pathways. However, when gene knockout technology has been used widely in mice o...学位：理学硕士院系专业：生命科学学院_生物学学号：2162013115259
