果蝇是研究抗病毒天然免疫以及病毒与宿主相互作用的理想模型。我们以果蝇C病毒（DrosophilaCVirus，DCV）为病原体对已有的突变体果蝇库进行筛选，找到了一个对DCV感染更为抵抗的果蝇株并鉴定出其体内Pelo基因的表达量下降。通过基因敲除和表型回复实验，我们证实了Pelo基因的缺失的确可以使果蝇对DCV的感染更为抵抗。此外，DCV以及其他多种病毒的复制在Pelo基因敲除型果蝇中都变慢，说明Pelo基因缺陷可能介导了广谱的抗病毒免疫。 我们研究发现，Pelo并不参与目前已知的果蝇抗病毒免疫途径，而是在蛋白质翻译水平特异性地调控DCVORF2蛋白的表达，并且这种调控不发生在蛋白翻译的起始...Drosophila is an ideal model for investigating antiviral innate immunity and virus-host interactions. We undertook a screen in drosophila for mutations involved in DCV (Drosophila C Virus) infection and found a viral resistant strain in which the expression of Pelo was deficient. We generated Pelo knockout fly pelo-/- and then demostrated that it was resistant to DCV infection and this phenotype c...学位：理学博士院系专业：生命科学学院_生物化学与分子生物学学号：2172009015355
