活性氧（ReactiveOxygenSpecies，ROS）的产生存在于生物体的众多生理病理过程中。大量的实验数据表明，活性氧还参与到了细胞凋亡和程序性坏死的进程里。丁基羟基苯甲醚（Butylatedhydroxyanisole，BHA）是公认的活性氧清除剂，异戊巴比妥（Amytal）是线粒体上电子传递到泛醌的抑制剂，二者都曾被广泛报道，可以抑制或者延缓肿瘤坏死因子（TumorNecroticFactorα，TNF-α）诱导的小鼠成纤维细胞系L929的程序性细胞坏死。然而，BHA和Amytal都不能抑制TNF诱导的人结肠腺癌细胞系HT-29的程序性细胞坏死。经过大量的研究，我们发现，不仅鼠源细...Reactive oxygen species (ROS) emerge during a number of physiological and pathological processes and their involvement in apoptosis and necroptosis has been widely reported. Butylated hydroxyanisole (BHA), an ROS scavenger, has been demonstrated to block or delay tumor necrotic factor α (TNF)-induced necroptosis in murine cell line L929, so as to Amytal, which can block electron flow to ubiquinone...学位：理学博士院系专业：生命科学学院_生物化学与分子生物学学号：2162012015378
