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dissecting of the role of nucleoporin seh1 in mice schwann cell development

Abstract

真核生物的核膜隔开了遗传物质和细胞质,这使细胞可以调控核质转运来调控细胞的多种生命活动。核膜上的核孔是由多种核孔蛋白组成的复合体,是介导核质转运的唯一的通道。最新的研究表明,核孔蛋白还参与了细胞周期的调控和机体的发育过程,尤其是神经系统发育的调控。Seh1是核孔蛋白亚复合体Nup107-160的组成成分,属于核孔复合体骨架核孔蛋白亚类。Nup107-160复合体作为NPC的主要结构组分,由九个亚基组成,负责调节mRNA的出核以及NPC的组装和分拆。现代研究表明,在细胞系和酵母中敲除Nup107-160复合体的亚基会阻碍有丝分裂中纺锤体的形成,染色体的分离以及胞质分裂,从而导致细胞周期的异常。由...Nuclear envelope of eukaryocyte separates the DNA and cytoplasm, which enable cell to regulate many kinds of program by controlling exchange between cytoplasm and cell nuclei. Nuclear pore complex (NPC) is the only way of transportation between cytoplasm and nucleus and locates in the nuclear envelope, consisted of lots of nucleoporins (Nups ). Recent study shows that Nups play roles in cell cycl...学位:理学硕士院系专业:生命科学学院_细胞生物学学号:2162013115252

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