疟疾是由疟原虫感染导致的蚊媒传染性疾病，每年导致全球上亿人口的感染和上百万人口的死亡，严重危害人类健康。疟原虫具有宿主交替和世代交替的特点，有脊椎动物和按蚊两个宿主，无性生殖和有性生殖两种生殖方式。配子体状态的疟原虫被按蚊吸食后，先后经历雌雄配子体—雌雄配子—合子—动合子—卵囊等发育阶段，这是一个多步骤、多基因调控的复杂过程，是疟疾传播的必须阶段。迄今为止，关于疟原虫配子体阶段特异表达基因的研究相对较少，本研究将重点分析约氏疟原虫配子体阶段特异表达基因的生物学功能。 通过比较鼠伯氏疟原虫ANKA虫株五个发育阶段的转录谱（4h环状体时期、16h滋养体时期、22h裂殖体时期、配子体时期及动合子时...Malaria is the mosquito-transmitted infectious disease caused by Plasmodium parasite. Almost one million people died from it and billions of people infected with malaria annually, endangering human health. The Plasmodium parasite resides in the alternative vertebrate and mosquito host, transitioning between asexual and sexual forms. Parasite gametocytes were transmitted to mosquito midgut within b...学位：理学硕士院系专业：生命科学学院_生物化学与分子生物学学号：2162013115259
