神经导向因子Netrins及Slits是人们在研究神经系统发育过程中被发现的，在神经轴突穿越中线的过程中，Slit/Robo信号与Netrin/DCC信号之间的协调互作对轴突顺利穿越中线并到达对侧靶点至关重要。在近年的研究中发现，Netrins及Slits家族对肿瘤的生长和转移也具有重要的作用，然而关于Netrin-1与Slit3及其相互作用在纤维肉瘤中的作用还鲜有报道。成纤维肉瘤细胞HT1080是高转移性的恶性成纤维肉瘤细胞，是研究肿瘤侵袭转移的常用模型，本论文对Netrin-1与Slit3及其相互作用对HT1080细胞在侵袭转移中的作用进行了探讨。 首先，我们研究了Netrin-1对HT...Neuronal guidance cue Netrins and Slits were found in studies on the nervous systems development. During the axon migrate through the midline, cooperation of Slit/Robo and Netrin/DCC signaling pathway plays important roles in axon pass through midline and reach its contralateral target site. Recent studies have found that Netrins and Slits participate in the development of tumors. However, there a...学位：理学硕士院系专业：生命科学学院_细胞生物学学号：2162013115256
