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Cloning, Expression and Immunolocalization of Aspartyl Protease Inhibitor Gene of Angiostrongylus cantonensis

Abstract

广州管圆线虫(Angiostrongyluscantonensis)是一种人畜共患自然疫源性寄生虫,能引起人的嗜酸性粒细胞增多性脑膜炎,也被称为广州管圆线虫病。其中间宿主是软体动物,例如福寿螺、玛瑙螺等,并以啮齿类动物等作为其终宿主。人类是广州管圆线虫的偶然宿主,因误食寄生有广州管圆线虫的第三期幼虫(L3)的福寿螺等而引起广州管圆线虫病。 寄生虫的天冬氨酸蛋白酶抑制剂(aspartylproteaseinhibitor,API)在寄生虫的寄生生活中起着重要的作用,包括寄生虫的营养摄取,组织入侵,免疫逃避,生长发育等等。本论文以广州管圆线虫为研究对象,以API基因作为研究的目的基因,对目的基因...Angiostrongylus cantonensis is a serious zoonoses parasite that causing parasitic, can cause eosinophilicmeningitis, also known as Angiostrongyliasis. its intermediate host is mollusca, such as apple snails, achatina fulica and so on. And parasitic on Glires as its final host. Human is the occasional host of this nematode, can catch theAngiostrongyliasis cantonensis by eating its infectivethird st...学位:理学硕士院系专业:生命科学学院_生物化学与分子生物学学号:2162012115230

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