阿兹海默氏症(Alzheimer’sdisease，AD)或称脑退化症、阿尔兹海默病、老年失智症等，由德国精神病学家和病理学家爱罗斯•阿兹海默(AloisAlzheimer)于1906年发现并因此得名。阿兹海默氏症的致病过程与淀粉样前体蛋白(Amyloidprecursorprotein，APP)解离的含有40或42个氨基酸的淀粉样多肽Aβ的错误折叠密切相关。淀粉样多肽从淀粉样前体蛋白中裂解产生后由分泌小泡分泌至细胞外，并发生折叠聚集，对神经细胞造成损伤，从而直接导致疾病的发生。Aβ聚集过程的机理研究，对于解释Aβ聚集体的神经毒性，进而研究有效的阿兹海默氏症的诊断与治疗试剂具有重要...Alzheimer’s disease (AD) was first described by German pathologist Alois Alzheimer in 1906. AD is the most common cause of dementia and one of the major hallmarks of the Alzheimer’s disease is the progressive deposition of Aβ protein fragments into β-sheet rich amyloid fibrils in excellular neuron cells. The Aβ protein fragment, cleaved from the amyloid precursor protein with β- and γ-secretases, ...学位：理学博士院系专业：化学化工学院_分析化学学号：2052009015329
