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Preparation andProperties of Fluorescent Gold Nanoclusters Functionalized Silk Biomaterials

Abstract

家蚕蚕丝作为天然的蛋白质纤维,具有独特的力学性能、良好的生物相容性和可控的生物降解性,已被作为生物医学理想材料。然而,蚕丝材料作为生物医学材料植入体内后,进行体内的检测和追踪仍是目前一大难点。本研究通过共混荧光金纳米簇和丝素蛋白,制备可用于体内荧光成像的蚕丝材料(3维支架、薄膜、凝胶),为生物材料的体内成像提供了思路。本研究主要内容如下: 冷冻干燥法制备三维多孔荧光丝素蛋白/金簇复合支架。复合支架具有红色荧光,研究发现丝素蛋白/金簇混合溶液的pH会影响金簇的荧光强度,发射峰位和荧光效率,支架荧光量子产率可达18%。金簇的加入增加丝素蛋白β-折叠和结晶度。丝素蛋白/金簇复合支架的孔洞之间相互贯...Bombyx mori silk fibers, as a natural protein, have been adsorbing great interests in the fields of biomedicine, due to robust mechanical properties, excellent biocompatibility and controllable biodegradation. However, the monitoring of the evolution of the overall structure and organization of the materials in vivo or in vitro remains as a neck bottle for the further refinement of silk bio-materi...学位:理学硕士院系专业:材料学院_生物医学工程学号:3142013115012

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