Background: Angiogenesis is involved in many cardiovascular and cancerous diseases, including
atherosclerosis and is controlled by a fine balance between angiogenic and angiostatic mediators.
Endostatin is one of the main angiostatic mediators, and inhibits angiogenesis and prevents
progression of atherosclerosis. The available literature shows a broad range of concentrations in
relatively small samples of healthy controls and is calculated by using different techniques. This
study was aimed to determine the basal endostatin concentration in plasma of healthy volunteers,
to fully understand its physiological role. Methods: Fifty healthy adult volunteers were recruited
to the study. Participants were advised not to participate in any physical activity on the day before
the blood sampling. The volunteers’ physical activity, height, weight, heart rate and blood pressure
were recorded. The samples were analysed for plasma endostatin concentration, using ELISA. The
participants were divided by gender and ethnic groups to calculate any difference. Results:
Endostatin and other variables were normally distributed. Most of the participants had a moderate
level of physical activity with no gender related difference (p=0.370). The mean value for plasma
endostatin in all samples was 105±12 ng/ml with range of 81–132 ng/ml. For males, it was 107±13
ng/ml, while for females; 102±12 ng/ml. There were no significant gender or ethnicity related
differences in endostatin concentration. Moreover, endostatin was not significantly related with
any anthropometric and physical variable. Conclusion: This study gives endostatin levels in
normal healthy people and show no gender and ethnicity related differences in endostatin levels.
Endostatin was not related with any anthropometric and physical variable
