Vitamin D receptor (VDR) gene variants are associated
with differential susceptibility or resistance to tuberculosis
in different ethnic groups. We investigated the polymorphisms
in the 5′ regulatory region of VDR gene in 206
normal healthy subjects and 166 patients with pulmonary
tuberculosis from south India. Cdx-2 polymorphism was
studied by polymerase chain reaction (PCR) with allelespecific
primers, while genotyping of A1012G was done
by PCR-based restriction fragment length polymorphism.
A significantly decreased frequency of Cdx-2 G allele
(P = 0.016) and G/G genotype (P = 0.010) and an increased
frequency of A-A haplotype (A allele of Cdx-2 and A allele
of A1012G) (P = 0.015) were observed in patients
compared to controls. The study suggests that Cdx-2
G/G genotype may be associated with protection and
A-A haplotype with susceptibility to tuberculosis