Biering-Sørensen, Tor

Joseph, Gowsini

Møgelvang, Rasmus

Nielsen, Gitte

Schnohr, Peter

Skov Jensen, Jan

Sogaard, Peter

English

Introduction: TDI (Tissue Doppler Imaging) is a sensitive marker of myocardial dysfunction and mortality in heart disease and in the general population. Regular physical activity is associated with risk reduction in coronary heart disease and mortality. There is a need for studies to clarify whether exercise has beneficial effects on cardiac function.Hypothesis: Regular physical exercise is associated with better cardiac function measured by TDI in the general populationMethods: 2,162 persons from the general population were examined by echocardiography and TDI. Peak systolic (s'), early diastolic (e') and late diastolic (a') velocities were measured by color TDI. Longitudinal displacement (LD) was calculated from the velocity curve during ejection. Statistical tests were performed by linear univariate and multivariable regression analyses, in relation to age groups (lt;50years, 50-65 years, gt;65 years) and physical activity level: I (inactivity), II (light activity), III (moderate activity) and IV (high-level activity). These levels were graded from the physical activity questionnaire, which contained information about activity level at work and in leisure time.Results: Participants agedlt;50 years had a significantly higher level of e' and LD in the most active group: e'=11.0 (textpm standard deviation, SD=2.0), plt;0.001; LD=12.8 (SD=2.1), plt;0.003. This pattern remained significant after adjusting for sex, hypertension, diabetes, and ischaemic heart disease and after Bonferroni correction. For e', there was significant interaction between age and activity level (plt;0.001), which supports the findings of better cardiac function with increasing activity among the young age group.Conclusion: In the general population, the association between increasing level of exercise and better cardiac function was found only in the youngest age group ( lt;50 years old). Among the elder age groups higher level of activity was not correlated to better cardiac function.Author Disclosures: G. Joseph: None. P. Sogaard: Other Research Support; Modest; GE Healthcare. G. Nielsen: None. T. Biering-Sorensen: None. P. Schnohr: None. J. Skov Jensen: None. R. Mogelvang: Other Research Support; Modest; GE Healthcare

    Aalborg UniversitetExercise and Cardiac Function by Tissue Doppler Imaging. The Copenhagen City HeartStudyJoseph, Gowsini; Sogaard, Peter; Nielsen, Gitte; Biering-Sørensen, Tor; Schnohr, Peter;Skov Jensen, Jan; Møgelvang, RasmusPublication date:2016Document VersionPublisher's PDF, also known as Version of recordLink to publication from Aalborg UniversityCitation for published version (APA):Joseph, G., Sogaard, P., Nielsen, G., Biering-Sørensen, T., Schnohr, P., Skov Jensen, J., & Møgelvang, R.(2016). Exercise and Cardiac Function by Tissue Doppler Imaging. The Copenhagen City Heart Study. Posterpresented at AHA Scientific Sessions 2016, New Orleans, United States.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            ? Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            ? You may not further distribute the material or use it for any profit-making activity or commercial gain            ? You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us at vbn@aub.aau.dk providing details, and we will remove access tothe work immediately and investigate your claim.Downloaded from vbn.aau.dk on: November 30, 2020Exercise and cardiac function by Tissue Doppler Echocardiography: The Copenhagen City Heart StudyGowsini Joseph*(1,2), Peter Søgaard(2,3,5), Gitte Nielsen(1), Tor Biering-Sørensen(4, 5), Peter Schnohr(5), Jan Skov Jensen(4,5), Rasmus Møgelvang(5,6)(1)Department of Cardiology, North Denmark Regional Hospital, Hjoerring, Denmark, (2)Aalborg University, Denmark, (3)Department of Cardiology, Aalborg University Hospital, Denmark,(4)Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, (5)Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark, (6)Department of Cardiology, Rigshospitalet, University of Copenhagen, Denmark*Corresponding author. Email: g.joseph@rn.dkBackgroundTDI (Tissue Doppler Imaging) is a sensitive marker of myocardial dysfunction and mortality in heart disease and in the general population.  Regular physical activity is associated with risk reduction in coronary heart disease and mortali-ty. There is a need for studies to clarify whether exercise has beneficial effects on cardiac function.HypothesisThe aim of this study was to test the hypothesis that regular physical exercise is as-sociated with better cardiac function measured by TDI in the general population.MethodsWithin a large prospective community-based population study, 2,053 persons were examined by conventional echocardiography and TDI. Peak systolic (s´), early di-astolic (e´) and late diastolic (a´) velocities were measured by colour TDI. Longi-tudinal displacement (LD) was calculated from the velocity curve during ejection. Statistical tests were performed by linear univariate and multivariable regression analyses, in relation to age groups (<50years, 50-65 years, >65 years) and physical activity level: I (inactivity), II (light activity), III (moderate activity) and IV (high-level activity). These levels were graded from the physical activity questionnaire, which contained information about activity level at work and in leisure time. ResultsParticipants aged<50 years had a significantly higher level of e´ and LD in the most active group: e´=11.0 (± standard deviation, SD=2.0), p<0.001; LD=12.8 (SD=2.1), p<0.003. This pattern remained significant after adjusting for sex, hy-pertension, diabetes, and ischaemic heart disease and after Bonferroni correction. Both e´ and LD were strongly correlated to age, thus being significantly different ConclusionIn the general population, the association between increasing level of exercise and better cardiac function was found only in the youngest age group ( <50 years old). Among the elder age groups, higher level of activity was not correlated to better cardiac function.  Disclosures: G. Joseph: None; P. Sogaard: Modest Research Support from GE Healthcare; G. Nielsen: None; T. Biering-Sorensen: None; P. Schnohr: None; J. Skov Jensen: None; R. Mogelvang: Modest Research Support from GE Healthcare.in the three age groups regardless of the activity level. This correlation remained highly significant after adjustments for potential confounders (p<0.001). For e´, there was a significant interaction between age and activity level (p<0.001), which supports the findings of better cardiac function with increasing activity in the young age group.  Table 1. Baseline Characteristics of the ParticipantsThe total population n=2,053Age 20-50y n=634Age 50-65y n=659Age >65 y n=760Age, y 58.3±16.0 38.7±8.2 58.4±4.4 74.5±6.2Male sex, % 42.7 45.6 48.7 35.0Body mass index, kg/m² 25.5±3.9 24.2±3.3 25.9±3.9 26.1±4.1Heart rate, bpm 67.1±11.3 64.8±10.8 67.8±11.5 68.3±11.2Hypertension, % 43.3 11.3 40.7 72.2Diabetes mellitus, % 10.1 4.6 10.5 14.3IHD, % 13.9 3.3 11.8 24.5 Table 2. Early diastolic myocardial velocity (e´) in relation to age group and activity level  Age 20-50 y Age 50-65 y Age > 65 yInactivity 9.21 (8.65-9.76) 6.59 (6.01-7.19) 4.96 (4.56-5.37)Light activity 9.86 (9.60-10.13) 6.86 (6.64-7.08) 5.07 (4.89-5.24)Moderate activity 9.82 (9.63-10.00) 7.05 (6.86-7.24) 5.16 (4.93-5.40)High level activity 11.00 (10.53-11.47) 6.80 (6.09-7.51) 5.01 (4.23-5.78)Table 3. Longitudinal displacement in relation to age group and activity level  Age 20-50 y Age 50-65 y Age > 65 yInactivity 11.52 (10.91-12.14) 10.69 (10.03-11.35) 9.40 (8.94-9.86)Light activity 11.73 (11.43-12.02) 10.41 (10.16-10.66) 9.35 (9.16-9.55)Moderate activity 11.76 (11.55-11.97) 10.86 (10.64-11.07) 9.44 (9.18-9.69)High level activity 12.82 (12.30-13.34) 10.23 (9.45-11.03) 9.86 (9.02-10.70)Longitudinal Displacement (LD, mean and 95% confidence interval) in relation to age group and activity level. E´ (mean and 95% confidence interval) in relation to age group and activity level. 

Exercise and Cardiac Function by Tissue Doppler Imaging. The Copenhagen City Heart Study

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Exercise and Cardiac Function by Tissue Doppler Imaging. The Copenhagen City Heart Study

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