Cannabinoids derivatives modify the pattern of sphingolipids in acute myeloid leukemia cells and produce a potent anti-leukemic effect

Abstract

2 p. 22nd Congress of the European Hematology Association. Madrid, Spain, June 22 - 25, 2017Endocannabinoid system is a set of ligands, receptors and endogenous enzymes which modulate a variety of physiological effects. There are two well-characterized cannabinoid receptors, CB1 (mainly expressed in Central Nervous System) and CB2 (mainly in hematopoietic cells). Here, we tested the effect of the cannabinoid WIN-55 212-2 in acute myeloid leukemia (AML) in vitro and in vivo and studied the molecular signaling pathways involved in this effect, specially the role of sphingolipids. Moreover, we synthesized a new family of twelve cannabinoids that are specific to CB2 receptor.Peer reviewe