Philosophiae Doctor - PhDTuberculosis (TB) is an infectious disease that, despite all efforts devoted towards its
eradication, remains a threat to many countries including South Africa. Current diagnostic
assays do offer better performance than the conventional sputum smear microscopy and
tuberculin skin tests. However, these assays have been proven to be affected by various factors
including the condition of an individual's immune system and vaccination history. By far,
electrochemical biosensors are amongst the currently investigated techniques to address the
shortcomings associated with these diagnostics