Lee, Diana Y

English

VCU Scholars Compass

Virginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2017May 18th, 6:30 PM - 7:00 PMBacteriophage Lifestyles: Capsid Size MattersDiana Y. LeeSan Diego State University, nuevecuervos@gmail.comFollow this and additional works at: http://scholarscompass.vcu.edu/bammPart of the Life Sciences Commons, Medicine and Health Sciences Commons, and the PhysicalSciences and Mathematics CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.http://scholarscompass.vcu.edu/bamm/2017/thursday/22Bacteriophages are superabundant in nearly all environments on Earth, from the deep sea to the human gut. Details on distribution of bacteriophage structures could lead to better understanding of which phages are more successful in various environmental niches and a richer understanding of their impact. With the advent of large datasets of phage genome data being produced via metagenomics, a high-throughput model to produce these distributions based on genome size would be ideal. We present an approach to such a model here. The model was developed using attributes of icosahedral tailed phages in order to address a majority of phages with one precise, repeatable method applicable to large data sets. Application of the model to these data sets produced distributions of T-numbers that closely match cited percentages for capsids expected to be icosahedral, and identified those groups with non-icosahedral capsid shapes. This result is promising, and leads to other lines of inquiry in order to refine the model, create related models for other phage groups and investigate what we can learn about the variance in capsid structure distribution. 

Bacteriophage Lifestyles: Capsid Size Matters

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1140&amp;context=bamm

Bacteriophage Lifestyles: Capsid Size Matters

Abstract

Similar works

Full text

Available Versions

VCU Scholars Compass