Reynolds, Angela

Segal, Rebecca

Torres, Marcella

English

VCU Scholars Compass

Virginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2017May 18th, 6:00 PM - 6:30 PMModeling macrophage polarization during theinflammatory phase of wound healingMarcella TorresVirginia Commonwealth University, torresmm@vcu.eduAngela ReynoldsVirginia Commonwealth University, areynolds2@vcu.eduRebecca SegalVirginia Commonwealth University, rasegal@vcu.eduFollow this and additional works at: http://scholarscompass.vcu.edu/bammPart of the Life Sciences Commons, Medicine and Health Sciences Commons, and the PhysicalSciences and Mathematics CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.http://scholarscompass.vcu.edu/bamm/2017/thursday/35Modeling macrophage polarization during the inflammatory phase of wound healing  Normal wound healing is a process driven, in part, by phagocytic cells and cytokine mediators.  In the inflammatory phase, debris, pathogen, and apoptotic cells are cleared from the wound by  macrophages and neutrophils and the activation of these cells is modulated by anti- and pro-  inflammatory cytokines. Macrophages can be activated to a more inflammatory M1 phenotype or to  an M2-like phenotype which promotes the resolution of inflammation. Problems with this phenotype  switch can result in the accumulation of too many of either type and lead to chronic wounds or  disease. We have developed an ordinary differential equation model that includes both macrophage  phenotypes to better understand the system dynamics and ultimately explore points of intervention  that can lead to homeostasis.   

Modeling macrophage polarization during the inflammatory phase of wound healing

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1185&context=bamm

Modeling macrophage polarization during the inflammatory phase of wound healing

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