Dvir, Hila

Fenton, Flavio H

Hardy, Neil

English

VCU Scholars Compass

Virginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2017May 19th, 11:30 AM - 12:00 PMOptimization of cardiac pacing stimulation bycurrent configuration –a theoretical, numerical andexperimental study.Flavio H. FentonGeorgia Institute of Technology, flavio.fenton@physics.gatech.eduHila Dvirdvirhila@gmail.comNeil HardyGerogia Tech, nhardy6@gatech.eduFollow this and additional works at: http://scholarscompass.vcu.edu/bammPart of the Biological and Chemical Physics Commons, Life Sciences Commons, and theMedicine and Health Sciences CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.http://scholarscompass.vcu.edu/bamm/2017/friday/6 Approximately 600,000 pacemakers are implanted annually worldwide, and more than 3 million people already have implanted pacemakers. The existing pacemakers emit a stimulation current in the form of a rectangular wave form. Using optimal control theory we derive the best waveform that stimulates cardiac tissue using the least amount of energy. Our main hypothesis is that the myocytes is not a passive component but rather a dynamic element. Specifically, the myocyte ion-channels currents act as an additional source of charge that sums up with the external stimulating charge for stimulation purposes. Therefore, as the action potential emerges (exponentially), the external stimulating current can be reduced accordingly. We tested the theoretically predicted best wave form first in silco using a one dimensional cable with a state of the art ionic cell model of human ventricular cells and found that we could reduce the energy by 60%. Then we tested them in ex vivo hearts of cats and rabbits. We found that energy to stimulate and initiate an electrical wave could be reduced up to 85% from the square pulse. This results could help save battery life and decrease tissue damage by continuous current stimulation.  

Optimization of cardiac pacing stimulation by current configuration –a theoretical, numerical and experimental study.

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1167&amp;context=bamm

Optimization of cardiac pacing stimulation by current configuration –a theoretical, numerical and experimental study.

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