E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Abstract
Site-specific genetic modification aiming to delete (knock-out) a gene provides an unequivocal answer to elucidate
the function of such particular gene in the whole organism. Site-specific genetic modification has been achieved by
homologous recombination, generally in embryonic stem cells, which has made the mouse the most widely used
mammalian model
