Impact of cerebral blood flow level on the fluctuations of resting-state BOLD fMRI in anesthetized rats

Abstract

International audienceThe Blood Oxygen Level Dependent (BOLD) signal, used in resting-state functional Magnetic Resonance Imaging (fMRI), is tighly linked to Cerebral Blood Flow (CBF). This study evaluates the impact of the CBF on the low-frequencies BOLD fluctuations and four physiological parameters during resting state in 5 groups of rats (Wistar and Long-Evans) anesthetized with Isoflurane, Medetomidine, Etomidate and Urethane. It is shown that the CBF is not related to physiological parameters, and there exists a range of CBF values where the BOLD fluctations are sufficiently high for being used in any other analysis

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