Similitude anisotrope, une transformation affine contrainte: application à l'analyse du développement cérébral

Abstract

International audienceThe study of brain development provides insights in the normal trend of brain evolution and enables early detection of abnormalities. We propose a method to quantify brain growth in three arbitrary orthogonal directions of the brain through linear registration. We introduce a 9 degrees of freedom transformation that gives the opportunity to extract scaling factors describing brain growth along those directions by registering a database of subjects in a common basis. We apply this framework to create a longitudinal curve of scaling ratios along fixed orthogonal directions from 0 to 16 years highlighting anisotropic brain development