Bourgois, Jan

Charlier, Ruben

Knaeps, Sara

Lefevre, Johan

Mertens, Evelien

Wijndaele, Katrien

English

Ghent University Academic Bibliography

See	discussions,	stats,	and	author	profiles	for	this	publication	at:	https://www.researchgate.net/publication/281967768Ten-year	change	in	sedentary	behavior	and	cardiorespiratory	fitness	are	independently	associated	with	clustered...Conference	Paper	·	September	2015CITATIONS0READS756	authors,	including:Some	of	the	authors	of	this	publication	are	also	working	on	these	related	projects:Ghent	Youth	Soccer	Project	View	project1.	Diving	reflex	from	a	cardiological	and	physiological	point	of	view	View	projectSara	KnaepsUniversity	of	Leuven19	PUBLICATIONS			1	CITATION			SEE	PROFILEJan	G	BourgoisGhent	University89	PUBLICATIONS			1,346	CITATIONS			SEE	PROFILEAll	content	following	this	page	was	uploaded	by	Sara	Knaeps	on	21	September	2015.The	user	has	requested	enhancement	of	the	downloaded	file.Is sitting the new smoking?Ten-year change in sedentary behavior and cardiorespiratory fitness are independently associated with clustered cardio-metabolic risk Sara Knaeps1, 2, Jan G. Bourgois 2, Ruben Charlier1, Evelien Mertens 1, 3, Johan Lefevre 1, Katrien Wijndaele 41 Physical Activity, Sports and Health Research Group, Department of Kinesiology, KU Leuven, Leuven, Belgium 2 Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium 3 Department of Human Biometrics andBiomechanics, Vrije Universiteit Brussel, Brussels, Belgium 4 MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UKCONCLUSIONA combination of decreasing sedentary behavior (SB) and increasing cardiorespiratory fitness (CRF) is mostbeneficial towards cardio-metabolic health, not moderate and vigorous physical activity (MVPA)Associations between CRF and cardio-metabolic risk were mediated through changes in waist circumference From a public health perspective, lifestyle interventions need to focus on lowering SB & increasing CRFINTRODUCTION A growing proportion of adults is inactive Sedentary behavior (SB) is highly prevalent, even in thosewho are sufficiently active Cardiorespiratory fitness (CRF) is a strong predictor forcardio-metabolic health Accumulating evidence has suggested that these threeexposures (SB, MVPA & CRF) contribute independentlyto unhealthier cardio-metabolic risk profiles. Central adiposity and nutritional intake negativelyinfluences cardio-metabolic health Important candidate to examine as potential mediatorAIM Examine the independent associations between change in sedentary behavior, MVPA and CRF and concurrent change in clustered cardio-metabolic risk over a ten-year follow up Whether any independent associations were mediated by change in central adiposity or nutritional intake Whether change in exposures interact with each otherMETHODS & MATERIALS2002-2004n = 1569 2012-2014n = 65242%9,62 (±0.52) years SB and MVPA were self-reported (FPACQ) CRF was determined by means of a maximal exercise test Cardio-metabolic Risk Score (CMRS): Standardized values (by sex andage) for waist circumference, fasting glucose, HDL-cholesterol,triglycerides, blood pressure were summed and divided by five CMRSno adip: CMRS without waist circumference and divided by four Statistical analyses: Multiple linear regression with standardized regression coefficients Mediation analysis by the product of coefficients (a*b) method by MacKinnon Interaction effects between change in exposures-0,25-0,15-0,050,050,150,25decrease DB increase 0-4 h/week Increase >4h+WeekChange in CMRSTertiles of SBInteraction CRF*SB for CMRSIncreasing CRFDecreasing CRFRESULTSTable 1. Standardized regression coefficients (β) of sedentary behavior, moderate-and-vigorous physical activity and cardiorespiratory fitness for cardio-metabolic markersChange in SBChange in MVPAChange in CRFChange in β β βCMRS 0.12** -0.08 -0.38***CMRSno adip 0.12** -0.10 -0.31***Waist Circumference 0.04 0.00 -0.39***Fasting Glucose 0.01 0.00 -0.12*HDL-cholesterol -0.09 0.15** 0.22***Triglycerides 0.12* -0.04 -0.19***Diastolic Blood Pressure 0.08 -0.08 -0.21***Systolic Blood Pressure 0.05 -0.01 -0.12***p<0.05; **p<0.01;***p<0.001 MULTIPLE LINEAR REGRESSIONModel = adjusted for age, follow-up time, sex, original study population,  baseline and changes in  healthy eating, smoking, education level;  changes and baseline of all three exposuresMEDIATION ANALYSISINTERACTION ANALYSISREFERENCES MacKinnon DP, Fairchild AJ, Fritz MS: Mediation analysis. Annual review of psychology 2007 Wijndaele K, Orrow G, Ekelund U, Sharp SJ, Brage S, Griffin SJ, Simmons RK: Increasing objectively measuredsedentary time increases clustered cardiometabolic risk: a 6 year analysis of the ProActive study. Diabetologia2014Figure 1.DECREASE IN SB INCREASE 0-4 H/WEEKINCREASE > 4H/WEEKCHANGEINCMRSNo decrease in CRFDecrease in CRFFigure 2. Estimated marginal means (SE)for change in CMRS in six groups ofparticipants, defined by their change inCRF (decrease (62%) and no decrease(38%) over time) and change insedentary behavior (decrease (37%),increase between 0-4 h/week (24%) andincrease by > 4h/week (39%)Figure 2.View publication stats

Is sitting the new smoking? : ten-year change in sedentary behavior and cardiorespiratory fitness are independently associated with clustered cardio-metabolic risk

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Is sitting the new smoking? : ten-year change in sedentary behavior and cardiorespiratory fitness are independently associated with clustered cardio-metabolic risk

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