Bisgaard, Hans

Bonnelykke, Klaus

Chawes, Bo

Heickendorff, Lene

Pedersen, Susanne Brix

Rasmussen, Morten

Stokholm, Jakob

Online Research Database In Technology

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Downloaded from orbit.dtu.dk on: Dec 18, 2017Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze inthe offspring: a randomised clinical trialChawes, Bo; Bonnelykke, Klaus; Stokholm, Jakob; Heickendorff, Lene; Pedersen, Susanne Brix;Rasmussen, Morten; Bisgaard, HansPublished in:Clinical and Translational AllergyPublication date:2016Document VersionPublisher's PDF, also known as Version of recordLink back to DTU OrbitCitation (APA):Chawes, B., Bonnelykke, K., Stokholm, J., Heickendorff, L., Pedersen, S. B., Rasmussen, M., & Bisgaard, H.(2016). Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: arandomised clinical trial. Clinical and Translational Allergy, 6(Suppl. 1), 6. [OP10].Page 6 of 60Clin Transl Allergy 2016, 6(Suppl 1):42twenty patients given needle acupuncture sessions by a rate same as laser group and group C (control group) under their asthmatic medica-tions only. Assessing of the clinical condition of the patient (frequency of attack and severity of asthma) and laboratory (IgE level and Eosino-phil count) before and after the study.Results: Frequency of asthmatic attack diminished in group A (p  <  0.001) more than in group B (p  =  0.002) and least in group C (p =  0.147) at the end of the study, Clinical severity of group A sig-nificantly improved (p  <  0.001) than group B and C, IgE level were significantly improved in both groups A and B (p < 0.001) better than changes occurred in group C (p = 0.057). Eosinophilic count showed more significantly improvement in group A (p < 0.001) than group B (p = 0.206) and group C (p = 0.784).Conclusions: Application of laser acupuncture sessions beside medi-cal treatment results in more significantly improvement of the asthma frequency of attack, the degree of asthma severity, IgE level and eosin-ophilic count in asthmatic children than the use of needle acupunc-ture or medications used only.OP09 The concentration of exhaled carbon monoxide in asthmatic children with different controlled stadiumPapp Gabor, Biro Gabor, Kovacs CsabaSzigetvar Hospital, Szigetvar, Hungary  Correspondence: Papp GaborClinical and Translational Allergy 2016, 6(Suppl 1):OP09Introduction: The exhaled carbon monoxide is an important bio-marker of the oxidative stress and the airways inflammation. Most scientific publications account of increase values in asthma. How-ever our known literature does not have data on the relationship between different stadiums of asthma control and the exhaled carbon monoxide values. The aim of this study was to access this correlation.Method: Our patients are well controlled, partly and uncontrolled asthma bronchial children, who are treated in outpatient clinic. Each of them has treatment according to GINA protocol. Before spirometry, patients were made deep inhalation, then they were made slow exha-lation to the carbon monoxide measure equipment. (PiCO + Smoker-lyzer) The exhaled carbon monoxide values were only known by the assistant, so that these values wouldn’t influence when putting in a cat-egory. We made the statistic by InStat softver. We used non-parametric procedures.Results: We found significant differences between the groups of well controlled and group of partly or uncontrolled in concentration of exhaled carbon monoxide, but significant difference was not demon-strable between the group of partly controlled and group of uncon-trolled (Table 1).Conclusion: According to our investigation/examinations the exhaled carbon monoxide is significantly higher in partly or uncon-trolled stadium of asthma bronchial than in well controlled stadium of asthma. This higher amount of exhaled carbon monoxide values show the raising of airways inflammation and the finish of well con-trolled stadium. The exhaled carbon monoxide suggests the inflam-mation aspect of asthma bronchial. Detailed analysis of our results shows that the eCO can be used to estimate the compliance of patients (Table 2).OP10 Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomised clinical trialBo Chawes1, Klaus Bønnelykke1, Jakob Stokholm1, Lene Heickendorff2, Susanne Brix3, Morten Rasmussen1, Hans Bisgaard11Danish Pediatric Asthma Center, Gentofte Hospital, University of Copen‑hagen, Gentofte, Denmark; 2Department of Clinical Biochemistry, Århus University Hospital, Århus, Denmark; 3Department of Systems Biology, Center for Biological Sequence Analysis, Technical University, Lyngby, Denmark  Correspondence: Bo ChawesClinical and Translational Allergy 2016, 6(Suppl 1):OP10Importance: Observational studies have suggested that increased dietary Vitamin D intake during pregnancy may protect the offspring against preschool wheezing, which is the most common disorder in young children.Objective: To determine whether supplementation of Vitamin D3 dur-ing third trimester of pregnancy reduces the risk of persistent wheeze in the offspring.Design, setting and participants: The study was a double-blinded, single-center, randomized controlled trial conducted within the Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) unselected mother–child cohort. A total of 627 women were recruited for the Vitamin D trial at 24 weeks of pregnancy, between March 4th 2009 and November 17th 2010. Clinical follow-up of the children (n = 581) was completed when the youngest child turned 3 years and unblinded on March 28th 2014.Intervention: Vitamin D3 (2400 IU/day) supplementation or matching placebo tablets from pregnancy week 24 to 1 week postpartum.Main outcome measure: Persistent wheeze at age 0–5  years diag-nosed solely by the intervention-blinded study pediatricians strictly adherent to a predefined algorithm based on 11 scheduled and addi-tional acute clinic visits and a day-to-day symptom diary filled by the parents from birth. Secondary outcomes were number of wheezy epi-sodes, asthma, neonatal airway immunology, respiratory infections, allergic sensitization and eczema.Results: Occurrence of persistent wheeze did not differ between the Vitamin D3 supplement and control group (incidence, 18 % vs. 21 %; hazard ratio, 0.79; 95 % CI, 0.54–1.14, P = 0.21). The number of wheezy episodes was reduced by the Vitamin D3 intervention (mean 5.9 vs. 7.2 episodes; incidence risk ratio, 0.83; 95  % CI, 0.71–0.97, P =  0.02) and the airway immune profile at age one month was up-regulated (prin-ciple component analysis, P = 0.04). There was no effect on additional end-points.Conclusion: The use of Vitamin D3 supplementation during pregnancy did not reduce the risk of persistent wheeze in the offspring.Table 1 SummaryWell  controlledPartly  controlledUncontrolled SignificanceNumber of patients99 (37 %) 102 (38 %) 68 (25 %)eCO (ppm) 3.21 (SD: 1.15)4.88 (SD: 2.60)5.55 (SD: 2.49) P < 0.0001Table 2 SummaryControlled Partly controlledUncontrolled Significant relationPatients number (male/female)99 (37 %) (51/48)102 (38 %) (62/40)68 (25 %) (36/32)–Age 11.13 11.23 10.97 p > 0.05FVC% 94.53 94.06 94.74 p > 0.05FEV1% 95.29 92.24 91.57 p > 0.05FEV1/FVC 88.24 85.68 85.41 P < 0.05 (p = 0.0186)FEF25–75 % 94.82 85.95 86.65 P < 0.05 (p = 0.0163)eCO/ppm/ 3.21 4.88 5.55 P < 0.05 (p < 0.0001)

Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomised clinical trial

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Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomised clinical trial

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