Arora

Barcenilla

Biagi

Carroll

Case

Chang

Cuiv

Cushing

David

Eeckhaut

Federhen

Furusawa

Galperin

Goodrich

Hofmann

Iino

Karlsson

Katano

Katoh

Keren

Kohl

Konikoff

Louis

Lurie-Weinberger

Mackie

Makivuokko

Malcomson

Misciagna

Mukherjee

Nielsen

Parte

Parthasarathy

Poulain

Schneider

Sokol

Sydenham

Tamura

Tigchelaar

Tims

Tripathi

Tuffery

Vandeputte

Vieira-Silva

Vrieze

Walker

Walters

Yanagita

Yatsunenko

Uri Gophna

Tom Konikoff

Henrik Bjørn Nielsen

Crossref

Environmental Microbiology

<i>Oscillospira</i>and related bacteria - From metagenomic species to metabolic features

Oscillospira is an under-studied anaerobic bacterial genus from Clostridial cluster IV that has resisted cultivation for over a century since the first time it was observed. In recent years its 16S rRNA gene was identified in several human gut microbiota studies where it was often associated with interesting traits, especially leanness. However, very little is known about its metabolism or physiology. Here we used nearly complete genomes derived from shot-gun metagenomic data from the human gut to analyze Oscillospira and related bacteria. We used sequence similarity, gene neighbourhood information and manual metabolic pathway curation to decipher key metabolic features of this intriguing bacterial genus. We infer that Oscillospira species are butyrate producers, and at least some of them have the ability to utilize glucuronate, a common animal-derived sugar that is both produced by the human host and consumed by that host in diets rich in animal products. These findings could help explain diet-related inter-individual variation in faecal Oscillospira levels as well as the observation that the presence of this genus is reduced in diseases that involve inflammation

Gophna, Uri

Konikoff, Tom

Nielsen, Henrik Bjørn

Online Research Database In Technology

Oscillospira and related bacteria - from metagenomics species to metabolic features

http://orbit.dtu.dk/ws/files/127983516/Oscillospira_and_related_bacteria.pdf

Oscillospira and related bacteria - from metagenomics species to metabolic features

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Crossref

Online Research Database In Technology