Asbach, Christof

Bau, Sebastien

Clausen, Per A.

Jankowska, Elzbieta

Jensen, Alexander

Jensen, Keld A.

Koivisto, Antti J.

Koponen, Ismo K.

Levin, Marcus

Mølhave, Kristian

Witschger, Olivier

Marcus Levin

Olivier Witschger

Se´bastien Bau

Elzbieta Jankowska

Ismo K. Koponen

Antti J. Koivisto

Per A. Clausen

Alexander Jensen

Kristian Mølhave

Christof Asbach

Keld A. Jensen

Crossref

Aerosol and Air Quality Research

Can We Trust Real Time Measurements of Lung Deposited Surface Area Concentrations in Dust from Powder Nanomaterials?

A comparison between various methods for real-time measurements of lung deposited surface area (LDSA) using spherical particles and powder dust with specific surface area ranging from 0.03 to 112 m2 g-1 was conducted. LDSA concentrations measured directly using Nanoparticle Surface Area Monitor (NSAM) and Aerotrak and were compared to LDSA concentrations recalculated from size distribution measurements using Electrical Low Pressure Impactor (ELPI) and Fast Mobility Particle Sizer (FMPS). FMPS and ELPI measurements were also compared to dust surface area concentrations estimated from gravimetrical filter measurements and specific surface areas. Measurement of LDSA showed very good correlation in measurements of spherical particles (R2 &gt; 0.97, Ratio 1.0 to 1.04). High surface area nanomaterial powders showed a fairly reliable correlation between NSAM and Aerotrak (R2 0.73-0.93) and a material-dependent offset in the ratios (1.04-2.8). However, the correlation and ratio were inconsistent for lower LDSA concentrations. Similar levels of correlation were observed for the NSAM and the FMPS for high surface area materials, but with the FMPS overestimating the LDSA concentration. The ELPI showed good correlation with NSAM data for high LDSA materials (R2 0.87-0.93), but not for lower LDSA concentrations (R2 0.50-0.72). Comparisons of respirable dust surface area from ELPI data correlated well (R2 &gt; 0.98) with that calculated from filter samples, but materials-specific exceptions were present. We conclude that there is currently insufficient reliability and comparability between methods in the measurement of LDSA concentrations. Further development is required to enable use of LDSA for reliable dose metric and regulatory enforcement of exposure

Online Research Database In Technology

http://orbit.dtu.dk/ws/files/126903816/1_AAQR_15_06_OA_0413_1105_1117.pdf

Can We Trust Real Time Measurements of Lung Deposited Surface Area Concentrations in Dust from Powder Nanomaterials?

Abstract

Similar works

Full text

Available Versions

Crossref

Online Research Database In Technology