A Løvdal

A Vaazjanen

AC Vieira

AJR Lasprilla

Alexandra Liv Vest Løvdal

AZ Rizvi

C Tsai

CD Mario

Christoph A. Binkert

CR Johnston

D Hayman

D Imberti

DJ Wallace

G Ginsberg

J Nuutinen

J Wu

JA Ormiston

JD Irving

K Lingaiah

K Miyazaki

Kasper Klausen

LS Nair

MD Eggers

MT Ke

NS Ditzhuijzen Van

S Calve

S Maddox

Sarah Calve

SD Thomas

Shuo Yang

T Nagata

TR Welch

William Van Alstine

X Ou

Y Wu

Crossref

CardioVascular and Interventional Radiology

Evaluation of a Bioabsorbable Self-Expandable Vein Stent-Base Made of Poly(l-lactide) In Vitro and In Vivo

Purpose  This study was designed to evaluate performance and tissue response to a self-expandable bioabsorbable vein stent-base cut from a tube with enhanced stiffness and strength in vitro and in vivo. Methods  A diamond-shaped stent-base was cut from a sequential biaxially strained poly(L-lactide) (PLLA) tube for optimized performance. The performance of the stent-base was evaluated in a finite element analysis model, and validation was attempted in vitro through a cyclic flat-plate compression and radial force measurement. The performance of the stent-base was tested in vivo using 3 sheep with 2 implants each for 2 and 3½ weeks, respectively. Results  In vitro the stent-base showed an elliptical deformation but no fractures. In vivo the stent-base showed adequate radial force and no migration. All implanted stent-bases showed multiple fractures not only at the predicted stress zones but at all connecting points. Fragments of the caudal stent-base stayed in the vein wall indicating sufficient tissue coverage to avoid embolization of the fractured stent pieces, whereas fragments from the cranial device remaining were few. Neointima formation was confirmed histologically at 2 and 3½ weeks. Conclusion  A bioabsorbable self-expandable stent-base made from PLLA for large veins seems feasible, but over time, the PLLA used in this study appears too stiff and lacks the sufficient flexibility to move with the vena cava, causing multiple fractures

Løvdal, Alexandra Liv Vest

Calve, Sarah

Yang, Shuo

Van Alstine, William

Binkert, Christoph A

Klausen, Kasper

Online Research Database In Technology

Evaluation of a Bioabsorbable Self-Expandable Vein Stent-Base Made of Poly(<sub>L</sub>-lactide) In Vitro and In Vivo

http://orbit.dtu.dk/ws/files/139749816/Alexandras_artikkel_post_print.pdf

Evaluation of a Bioabsorbable Self-Expandable Vein Stent-Base Made of Poly(<sub>L</sub>-lactide) In Vitro and In Vivo

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Crossref

Online Research Database In Technology