We address the issue of control of a stochastic two-component granulation
process in pharmaceutical applications through using Stochastic Model
Predictive Control (SMPC) and model reduction to obtain the desired particle
distribution. We first use the method of moments to reduce the governing
integro-differential equation down to a nonlinear ordinary differential
equation (ODE). This reduced-order model is employed in the SMPC formulation.
The probabilistic constraints in this formulation keep the variance of
particles' drug concentration in an admissible range. To solve the resulting
stochastic optimization problem, we first employ polynomial chaos expansion to
obtain the Probability Distribution Function (PDF) of the future state
variables using the uncertain variables' distributions. As a result, the
original stochastic optimization problem for a particulate system is converted
to a deterministic dynamic optimization. This approximation lessens the
computation burden of the controller and makes its real time application
possible.Comment: American control Conference, May, 201