International audienceThis Strategic Research Agenda is the fourth High Performance Computing (HPC) technology roadmap developed and maintained by ETP4HPC, the European High-Performance Computing Platform with the support of the EXDCI-2 project. It continues the tradition of a structured approach to the identification of key research objectives. The main objective of this SRA is to identify the European technology research priorities in the area of High-Performance Computing (HPC) and High-Performance Data Analytics (HPDA), which should be used by EuroHPC to build its 2021 – 2024 Work Programme.Over eighty HPC experts associated with member organisations of ETP4HPC created this document in collaboration with external technical leaders representing those areas of technology that together with HPC form what we have come to call “The Digital Continuum”. This new concept well reflects the main trend of this SRA – it is not only about developing HPC technology in order to build competitive European HPC systems but also about making our HPC solutions work together with other related technologies - the material included in this SRA is also a result of our interactions with Big Data, Internet of Things (IoT), and Artificial Intelligence (AI) and Cyber Physical Systems (CPS)