Acquired brain injuries can lead to cognitive, emotional as well as behavioural sequelae and can have a great impact on the affected person and his or her family. Over the last decade, pharmacological treatment has become an important part of brain injury rehabilitation. There is increasing clinical experience of the use of various drugs affecting neurotransmitters and cerebral function, but the scientific evidence is still limited. Within rehabilitation medicine there is also broad knowledge of when after a brain injury drugs can be used and which drugs that are potentially harmful and can negatively impede on post-injury recovery. In this review, we describe some brain injury signs and symptoms that commonly occur during rehabilitation and how pharmacological intervention can be used to treat these signs and symptoms