The reference strain, Mycobacterium tuberculosis
H37Rv, 19 drug-sensitive and 15 drug resistant clinical
isolates of M. tuberculosis were tested for their in
vitro susceptibility to trifluoperazine (TFP), an
antipsychotic drug, by broth dilution method. The
minimal inhibitory concentration (MIC) and minimal
bactericidal concentration (MBC) of TFP against M.
tuberculosis H37Rv were 8 and 32 mg/l, respectively.
The distribution of the sensitive and resistant isolates,
with respect to the MIC of TFP, was similar. The
distribution of the sensitive and resistant isolates,
with respect to the MBC of TFP, was different and
the difference was statistically significant. The findings
suggest that TFP is more bactericidal to drug-resistant
isolates than to the sensitive isolates
