Cell mediated immunity was assessed in 30
children with acute post streptococcal glomerulonephritis
(APSGN) in parallel with 20 normal children
and 15 children without nephritis who showed evidence
of skin-sore ß-Hemolytic streptococcal
infection. Delayed cutaneous hypersensitivity to
2,4, dinitrochloro benzene (DNCB) was similar in
the three groups. There were no significant differences
in the proportion of early and total T-rosettes.
Lymphocyte transformation response to phytohemagglutinin-
P (PHA), purified protein derivative
(PPD) and BCG was similar in them, indirect leucocyte
migration inhibition response to PPD, streptokinase
streptodornase (SK-SD), and group A ß-Hemolytic
T12 streptococcal antigens were not significantly
different in patients when compared to normal controls
and streptococcal infection controls. Cell mediated
immunity was normal in APSGN in children by all
the parameters studied