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Surface markers of lymphoblasts in acute lymphoblastic leukaemia

Abstract

58 children with acute lymphoblastic leukaemia (ALL) were studied for the effect of initial clinical and laboratory features and surface markers of lymphoblasts on the prognosis. 18.9% of them had T cell leukaemia while 3.4% had B-cell leukaemia. Six pre-treatment features were related to T-cell ALL, i.e. - age over 6 years, boys, presence of mediastinal enlargement, haemoglobin over 8g/dl, markedly elevated leucocyte count and CNS involvement. 90% of T-Cell ALL survived for less than 6 months. Both the cases of B-cell leukaemia died within 8 weeks. Identification of T and B cell leukaemia warrants more aggressive treatment for these patients to achieve remission and survive longer

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