BATTAGLIA, Salvatore

BELLIA, Maria

BELLIA, Vincenzo

Benfante, A

Brown RH

Cannizzaro, F

MIDIRI, Massimo

SCICHILONE, Nicola Alessandro

Archivio istituzionale della ricerca - Università di Palermo

25/05/13 Printing Toolabout:blank 1/1 [Poster Board # 515] Airway Wall Thickness By HRCT Does Not Affect Airway DistensibilityIn Asthma And COPD, [Publication Page: A3737]N. Scichilone, MD1, A. Benfante, MD1, M. Bellia, MD1, F. Cannizzaro, MD1, M. Battaglia, MD1, M.Midiri, MD1, R.H. Brown, MD, MPH2, V. Bellia, MD1 1Palermo/IT, 2Baltimore, MD/USRationale. In asthma and COPD, the functional alterations can be defined not only by the degree ofbronchial obstruction but also by the magnitude of the airway distensibility (AD) in response to deepinspirations (DIs). The current study was designed to test the hypothesis that airway wall thickness affectsthe DI-induced AD as assessed by HRCT. To this aim, we tested AD in patients affected by asthma andCOPD with comparable degree of bronchial obstruction.Methods. Twelve asthmatics (M/F: 7/5) and 8 COPD (M/F: 7/1) with comparable degree of bronchialobstrution (FEV1% pred.: 69.0±4.8% vs. 61.3±5.9%, p=0.31; asthma vs. COPD) were submitted toclinical and functional evaluation. Subjects underwent HRCT evaluation, performed by spiral computedtomography. AD was measured by applying the following formula to each individual airway: (Airwaydiameter at TLC – Airway diameter at FRC)/ Airway diameter at FRC. Airway wall thickness was alsocalculated by using the VIDA software, and expressed as a fraction of the diameter (AWF).Results. A total of 701 airways (range 20 to 38 airway per subject; 2.0 to 23.1 mm in diameter) wereanalyzed. Mean AD was 14±3.5% in asthmatics and 17±4.3% in COPD (p=0.58). No significantdifferences between the two groups were detected when AD was calculated for the small (p=0.27), themedium (p=0.94) and the large (p=0.40) airways, respectively. We did not find significant differencesbetween groups in mean airway wall thickness (at TLC: 0.52±0.01% in asthmatics and 0.51±0.01% inCOPD, p=0.50; at FRC: 0.55±0.01% in asthmatics and 0.55±0.01% in COPD, p=0.94). Also, we didnot detect any difference between groups in AWF when airways were examined by size (between groupsANOVA: p=0.21, p=0.8, p=0.07 for small, medium and large airways, respectively). To explorewhether AWF influences the degree of AD, we performed simple linear regression analyses, which didnot yield any statistically significant association.Conclusions Contrary to the concept that increased thickness of the airway wall, such as that observedin the more severe stages of chronic obstructive diseases, could induce greater stiffness of airways, thusopposing airway distension, we did not demonstrate any association between airway wall thickness anddistensibility of the airways. Other factors, such as those related to the parenchyma (i.e. airway-to-parenchyma interdependence), should be considered.Am J Respir Crit Care Med 187;2013:A3737Session Info: Poster Discussion Session, [B109] TECHNOLOGIC ADVANCES IN IMAGINGFOR PHENOTYPING LUNG DISEASEDay/Date: Monday, May 20, 2013Session Time: 2:00 PM - 4:30 PMPoster Viewing: 2:00 PM - 3:00 PMDiscussion: 3:00 PM - 4:30 PMRoom: Room 201 C (200 Level) Pennsylvania Convention Center

Airway Wall Thickness By HRCT Does Not Affect Airway Distensibility
In Asthma And COPD

https://iris.unipa.it/retrieve/handle/10447/74515/74917/poster%20ats%202013.pdf

Airway Wall Thickness By HRCT Does Not Affect Airway Distensibility In Asthma And COPD

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Archivio istituzionale della ricerca - Università di Palermo