Two cases of Wilson's disease occurring in the Maltese Islands are described and their response to Penicillamine therapy together with various aspects of Penicillamine therapy discussed. The first case is particularly interesting as dramatic clinical recovery occurred in spite of seven years of complete incapacity from the disease, implying that the neurological disturbance in Wilson's disease is always potentially reversible, however severe the degree and prolonged the duration of the initial incapacity before therapy is started. Perhaps one of the most striking clinical features in one of the patients described above is the fact that there had been seven years' total incapacity before treatment with Penicillamine was instituted.peer-reviewe
