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Lab‐on‐a‐chip biophotonics: its application to assisted reproductive technologies
Authors
Alvarez
Antinori
+43 more
Beebe
Borini
Brison
Chen
Cho
Chung
Croxatto
Dunn
Folch
Garcia
Gardner
Gardner
Glasgow
Han
Heo
Heo
Heo
Hwang
Jeyendran
Katz-Jaffe
Kuwayama
Lane
Lane
McCormack
Mosadegh
Nicholson
Nir
Ohta
Scott
Seidel
Seli
Shi
Shim
Smith
Smith
Suh
Tomlinson
Urbanski
Valley
Vergouw
Willadsen
Wong
Zeggari
Publication date
1 August 2012
Publisher
'Wiley'
Doi
Cite
Abstract
With the benefits of automation, sensitivity and precision, microfluidics has enabled complex and otherwise tedious experiments. Lately, lab‐on‐a‐chip (LOC) has proven to be a useful tool for enhancing non‐invasive assisted reproductive technology (ART). Non‐invasive gamete and embryo assessment has largely been through periodic morpohological assessment using optical microscopy and early LOC ART was the same. As we realize that morphological assessment is a poor indication of gamete or embryo health, more advanced biophotonics has emerged in LOC ART to assay for metabolites or gamete separation via optoelectrical tweezers. Off‐chip, even more advanced biophotonics with broad spectrum analysis of metabolites and secretomes has been developed that show even higher accuracy to predicting reproductive potential. The integration of broad spectrum metabolite analysis into LOC ART is an exciting future that merges automation and sensitivity with the already highly accurate and strong predictive power of biophotonics. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/92358/1/650_ftp.pd
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