Use of the collections of pathogenic bacteria from the Microbial Resource Centre CIRM-BP to evaluate the antibacterial potential of candidate molecules

Abstract

International audienceThe International Centre for Microbial Resource dedicated to pathogenic bacteria (CIRM-BP) is located within the French National Institute for Agricultural Research (INRA) centre of Val de Loire. The activity of the CIRMBP is dedicated to the conservation and the distribution of strains of bacterial pathogens isolated from animals or from human as well as the distribution of their genomic DNAs. The CIRM-BP is ISO 9001 certified since 2008. Its collection comprises around 2500 strains belonging to 57 genera and 167 species of bacteria of risk groups 2 and 3. The CIRM-BP offers services related to strain identification, characterization and preservation. The CIRM-BP also develops scientific partnerships for studying biodiversity. Beside these activities, the CIRM-BP takes advantage of its collections of pathogenic strains to study the antibacterial potential of different molecules proposed by its collaborative partners. In that aim, a panel of pathogenic bacterial strains is first constituted considering the intended target for the candidate molecules (for example pathogenic bacteria specific of the production systems of farm animal). This leads to the choice of the bacterial species to be tested and of the strains, in function of their origin and context of isolation