An efficient and simple one-pot synthesis of 2-perfluoroalkylated benzo[1,3]dioxole derivatives via double–Michael reaction of fluorinated alkynes

Abstract

International audienceAn efficient, mild and very easy method for the synthesis of 2-fluoroalkylated 1,3-benzodioxole derivatives was developed through a double Michael-addition reaction on ethyl 4,4,4-trifluorobut-2-ynoate with corresponding catechols. The procedure does not require the use of expensive supplementary additives for the preparation of 2-fluoroalkylated benzo ketals