Abbas, Amr

Goldstein, James

Hanson, Ivan

Madder, Ryan

Safian, Robert

Smith, James L.

Zacharias, Sibin

Elsevier - Publisher Connector 

TCT@ACC-i2: The Interventional Learning Pathway
A1778
JACC April 1, 2014
Volume 63, Issue 12
PAthology of feMoro-PoPliteAl Atherosclerosis: no role of liPiD core?
Poster Contributions
Hall C
Saturday, March 29, 2014, 3:45 p.m.-4:30 p.m.
Session Title: IVUS and Physiology
Abstract Category: 35. TCT@ACC-i2: IVUS and Intravascular Physiology
Presentation Number: 2103-294
Authors: James L. Smith, Sibin Zacharias, Ivan Hanson, Ryan Madder, James Goldstein, Robert Safian, Amr Abbas, Beaumont Health System, 
Royal Oak, MI, USA, Spectrum Health System, Grand Rapids, MI, USA
background:  Autopsy studies have demonstrated differing characteristics of atherosclerosis depending on the arterial bed. Lipid core plaque 
(LCP) has been identified in the coronary circulation, but its presence in the superficial femoral artery (SFA) has not been evaluated invasively. 
Previous MRI studies suggested a differential LCP between eccentric and concentric lesions. We sought to assess the presence of LCP in SFA 
stenosis.
Methods:  Twelve consecutive patients undergoing SFA revascularization were scanned by near infrared spectroscopy (NIRS) and intravascular 
ultrasound (IVUS) for the detection of LCP prior to intervention. LCP, and lipid core burden index (LCBI) were then co-registered to the area of most 
severe stenosis in the artery by IVUS. Two patients underwent atherectomy with pathologic analysis.
results:  In total, 12 patients underwent 18 scans of the SFA at sites of severe stenosis. The average length of vessel scanned was 78±31 mm with 
each scan. Of the 18 spectroscopic analyses, 16 (89%) had no LCP present at areas of stenosis. In both patients with atherectomy, no lipid core 
was identified on pathology. Of the 2 patients with LCP present at the site of stenosis, the mean LCBI was 297±86. Both plaques were negatively 
remodeled with circumferential calcification.
conclusions:  The data suggests, as previously reported by other modalities, that LCP does not constitute a major process in the negative 
remodeling of atherosclerosis in SFA stenosis.
 


PATHOLOGY OF FEMORO-POPLITEAL ATHEROSCLEROSIS: NO ROLE OF LIPID CORE? 

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PATHOLOGY OF FEMORO-POPLITEAL ATHEROSCLEROSIS: NO ROLE OF LIPID CORE?

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